PTT-6® and its Proven Effects on Hair Follicles

When it comes to hair loss treatments, there are tons of remedies that claim to reverse the condition. How true are these claims? Sifting the facts from fallacies can be an uphill task for hair loss sufferers looking for a solution for their condition. It is a good practice to look for solutions that are verified by medical practitioners with robust clinical data, such as CALECIM®’s Advanced Hair System, that makes its appearance in a recent medical article in the peer-reviewed PMFA.

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CALECIM®’s Advanced Hair System is a science-backed treatment that uses stem cell technology to regenerate hair. Its patented exosome ingredient — PTT-6® — has been found to be effective in treating hair loss, affirmed a peer-reviewed article. In this article, the world’s leading stem cell hair experts shared their research and expertise and concluded that stem cell exosomes, in the form of PTT-6®, offer a revolutionary new approach to hair loss.

Why is a peer-reviewed article information that you can trust? Essentially, peer review is an academic term for information that is quality controlled.  When an article is peer-reviewed, it mean it has been examined by a panel of reviewers who are experts on the article's topic. Among the things that these experts look out for are the proper use of research methods, as well as the significance of the paper’s contribution to the existing literature. Papers published in these journals are expert-approved…and are considered the most authoritative source of information and can even be used for college-level research papers. 

The article which mentions PTT-6® for hair growth appeared in the Dec/Jan 2024 issue of the PMFA journal and is co-authored by top specialists in hair restoration and aesthetic medicine, such as Dr Neil Sadick and Dr Munir Somji. Stated Dr Sadick, “red deer USL-MSC exosomal proteins (otherwise known as PTT-6®) could suppress inflammation as effectively as vitamin D with resultant increase in hair growth from reactivation of dormant hair follicles in the telogen phase”.

Exosomes are a bubble-like membranous structure that are produced by all cell types. They store and transport cellular products, and digest metabolic wastes within a cell. They also contain a variety of molecules such as cytokines, growth factors, peptides, lipids and nucleic acids. The proportion of cytokines and growth factors contained in exosomes is specific to the cell type from which they are produced. Cytokines and growth factors are able to stimulate cell growth. The umbilical cord lining, the patented source of stem cells that is utilized by CALECIM, contains both mesenchymal and epithelial stem cells that secrete exosomes that promote cellular repair, regeneration and renewal.

In human studies, topical application of red deer umbilical cord lining extract (also known as PTT-6®) to the scalp of a patient suffering from post-COVID-19 telogen effluvium was shown to result in hair regrowth. Similar positive results were demonstrated when using PTT-6® on 60 patients with medical alopecia therapy. To suppress inflammation, PTT-6®l proteins were applied topically on the scalp after microneedling. Hair regrowth and improved hair texture and density were reported in 90% of patients with no adverse effects.

A London-based trichologist treated male and female patients with androgenetic alopecia with weekly applications of PTT-6® following micro needling. She found improvements in hair growth and quality up to six months after treatment. Interestingly, those with greying hair saw a darkening of hair colour. Similar results were seen in tests done in Singapore and Australia.

Another patient with alopecia areata who was given the same treatment saw improvements in hair growth after six weekly hair treatments.

The finding that PTT-6® can suppress inflammation effectively with resultant increase in hair growth from reactivation of hair follicles in the resting phase of the hair growth cycle suggests that active inflammation at the dermal papilla arrests hair growth and suppression of inflammation allows hair regrowth.

Just as stem cell exosomes help speed up wound healing, so do they aid in activating the hair follicle. The mechanisms involved in the wound-healing process are likely to be similar, with the suppression of inflammation and resultant increase in hair growth from reactivation of hair follicles, concluded the PMFA article.

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