Whether we’re talking about wound healing, treating chronic illness, or advancing anti-aging skin care—stem cell research holds the key to the future. CellResearchCorp. has discovered and patented an ethical, abundant source of stem cells drawn from mammalian umbilical cord lining membrane. This discovery represents a breakthrough in advanced skin care.

While most stem cell-derived products on the market use adult stem cells or plant stem cells, CellResearchCorp. draws from neonatal mammalian stem cells to formulate CALECIM® Professional serums and creams. These youthful cells are the reason CALECIM® skin care produces such visible results so quickly.

Here’s a closer look at how neonatal and adult stem cells compare in a cosmetic context:

Isolation and Cultivation

CellResearchCorp. holds patents in 41 territories worldwide for a technique that easily isolates mesenchymal stem cells (MSC) and epithelial stem cells (EpSC) from the umbilical cord lining membrane. Once isolated, neonatal cells are known to grow easily in culture. In contrast, adult stem cells, while found in many tissues and organs of the body, are hard to isolate; and once isolated are difficult to cultivate in the lab.

Stem Cell Yield

To develop its effective conditioned media, CALECIM® needs access to a bountiful source of stem cells. As we age, the population of stem cells in our body decreases, making it difficult to harvest a high number of cells. For example, the ratio of MSC to differentiate cells in bone marrow at birth is one in 10,000. By 30 years of age, that number drops to one in 250,000; and by 50 it’s one in 400,000.

Contrast those figures to the 20 million MSC explanted per square centimeter of cord lining membrane, and you’ll understand how this extremely high yield of stem cells enables CALECIM® to formulate products with a high quality active conditioned media. In fact, CellResearchCorp’s technology holds the potential to harvest an incredible 6,000,000,000 MSC from a single umbilical cord in one generation. In fact, Cord Lining Stem Cells can divide for 30 generations without a change in the viability of the stem cells. The umbilical cord lining also contains epithelial stem cells in equally abundant numbers which are crucial for maintaining the health of the epidermis.

Stem Cell Activity and Potency

As we age, not only does the absolute number of stem cells in our bodies decrease, but a number of protein signals in the form of cytokines and growth factors is also diminished. Agi, therefore, e reduces the effectiveness of MSC in our bodies.

Youthful neonatal stem cells, on the other hand, are remarkably robust and active, and the biochemical signals they secrete and send to other cells—directing them to repair and regenerate — are equally robust and potent.

Other Factors:

The harvesting of neonatal umbilical cord lining stem cells patented and conducted by CellResearchCorp. is non-invasive as the cord lining comes from afterbirth delivered after the birth of a newborn. It is thus a painless process with no adverse effects to the donor. Both epithelial and mesenchymal stem cells are available from the same source, so both epidermal and dermal layers of skin are addressed by CALECIM® products derived from these stem cells.

Taken together, we see why neonatal stem cells used in CALECIM® Professional products compare favorably with adult stem cell-derived alternatives. However, the proof, as they say, is in the pudding. The best way to experience the difference is to visit one of our partner physicians and discover CALECIM® for yourself.