Over a Decade of Stem Cell Research

Stem cell research is probably the most exciting field in science to touch the skin care industry in a long time. At CALECIM® Professional, we’ve harnessed more than 10 years of stem cell research by our parent company CellResearchCorp and created a new and completely ground-breaking cosmeceutical.

To understand the science that makes CALECIM® Professional products unique, it’s necessary to understand more about the fascinating cells it comes from, how they communicate, and the possibilities they hold.

The Importance of Stem Cells

Stem cells are unique; they can differentiate into specialized cells or divide to produce more stem cells of their own type, they are responsible for healing, maintaining growth, and replacing the old cells in our skin. As we age, the numbers and activity of the stem cells in our body and skin slowly decrease. As they do, our skin gradually loses its ability to repair and restore itself, and hence, we start to see signs of aging.

The source of Our Stem Cells: to Deliver Stem Cell Therapy for Your Skin

CellResearchCorp obtains stem cells to produce CALECIM® Professional from the umbilical cord lining membrane of red deer. The umbilical cord lining membrane, in both humans and other mammals, is the most abundant source of Epithelial and Mesenchymal stem cells known to date. The numbers that can be harvested vastly exceeds any other source, including bone marrow and fat. The stem cells isolated from cord lining membrane are neonatal cells, and as such are much more potent and robust compared to their adult sourced counterparts.

Stem Cells Types and Their Functions

In 2004, CellResearchCorp discovered Cord Lining Stem Cells and patented culture techniques to isolate both epithelial stem cells and mesenchymal stem cells from the cord lining membrane. These cells hold special interest as they govern the body’s ability to heal and regenerate.

Epithelial Stem Cells (EpSC)

EpSC carry out the renewal of epithelial tissues. Epithelial tissue covers outer and inner surfaces of the body. In addition to the skin, it also lines the digestive and respiratory tracts. Within the skin, the innermost layer of the epidermis holds stem cells which continually create new cells to replace those that are old or damaged.

Mesenchymal Stem Cells (MSC)

MSCs play a major role in the body’s defense against injury and stress. They are able to differentiate into a variety of stem cell types, including bone, nerve, and fat cells. MSCs can also travel within the body to the location of a wound or injury to direct the healing response.

How Cells Talk To Each Other (Intercellular messages): All About Growth Factors and Cytokines

Both EpSC and MSC communicate with each other, and other cell types, through secreted proteins called cytokines. These unique cytokines cellular messages trigger specific receptors on cell membranes, creating targeted responses. When new cell growth or protein synthesis happens in the skin, it’s a result of these cytokine messages being sent from stem cells to cells in the dermis and epidermis. We call these cytokines “youth-messages” or “power-proteins” as they essentially can tell your skin to act younger.

However, it is worthy to note that EpSC and MSC do not perform their tasks entirely on their own. They are also influenced by epithelial-mesenchymal interactions, which take place at the interface between the epithelium (where EpSC are found) and the mesenchyme just beneath (where MSC are found).

Obtaining Conditioned Media from Stem Cells: The Making of a Unique Stem Cell Skincare

Stem cells are grown in a cultivating solution called Culture Medium, where they secrete cytokines, growth factors and proteins. Culture Medium which now contains all these proteins secreted by the Stem Cells is called Conditioned Media. The conditioned media is collected, leaving the stem cells behind, to make CALECIM® Rejuvenating Conditioned Media. CALECIM® Rejuvenating Conditioned Media is essentially a power cell-growth medium that has been conditioned by epithelial and mesenchymal stem cells.

The Anti-Aging Results from Daily Stem Cell Therapy for Your Skin

Every CALECIM® Professional product contains an optimal concentration of CALECIM® Rejuvenating Conditioned Media, which works to restore and rejuvenate the skin. Applying this rejuvenating conditioned media to the skin has shown to speed up healing, dramatically improve the skin’s appearance, and effect structural changes in the skin over time. The result is the correction of various aging symptoms such as loss of skin fullness, volume, and facial definition, as well as lines and wrinkles, pigmentation and loss of skin density and elasticity. With its powerful medium of “youth- messages”, CALECIM® Professional is able to show positive results in as little as two weeks. See the results yourself in these clinical trials.

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